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General Information
Symbol
Dmel\HndsRNA.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0277053
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences positioned at either end of the coding region drive expression of a full-length Hn cDNA, in both sense and antisense orientation, resulting in the generation of dsRNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Significant embryonic lethality is observed upon expression of HndsRNA.Sym.Scer\UAS under the control of Scer\GAL4da.G32. However, later development is unaffected as adult eclosion levels are unchanged.

Knockdown of Hn in the larval fat body and haemocytes through expression of HndsRNA.Sym.Scer\UAS under the control of Scer\GAL4Cg.PA results in a significant increase in locomotion relative to controls, at both the first and second days of the third-instar larval stage. Mouth hook contractions are significantly increased in these larvae. No changes in white prepupal heart rate are found.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
HndsRNA.Sym.Scer\UAS
HndsRNA.Sym.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)