Allele Dmel\cmet^A1C5

General Information
Symbol	Dmel\cmet^A1C5	Species	D. melanogaster
Name		FlyBase ID	FBal0277084
Feature type	allele	Associated gene	Dmel\cmet

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Gerhold et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q1244@. (Gerhold et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	size defective \| adult stage (Gerhold et al., 2011) size defective \| adult stage \| conditional (Gerhold et al., 2011) size defective \| adult stage \| heat sensitive (Gerhold et al., 2011) visible \| adult stage (Gerhold et al., 2011) visible \| adult stage \| conditional (Gerhold et al., 2011) visible \| adult stage \| heat sensitive (Gerhold et al., 2011)
Phenotype Manifest In
	eye (Gerhold et al., 2011) eye \| conditional (Gerhold et al., 2011) eye \| heat sensitive (Gerhold et al., 2011)
Detailed Description
	Statement Reference Homozygous cmet[A1C5] mutant eyes show moderate to strong defects in compensatory growth in response to tissue loss (induced by generating larval clones of the temperature-sensitive cell-lethal mutation sec5[ts1] under the control of Scer\GAL4[en-e16E] at the restrictive temperature). The resulting eyes are smaller than wild type. Weak to moderate defects in cell proliferation are also detected when the sec5[ts1] cells are not ablated (i.e. when the flies are maintained at the permissive temperature). The proportion of mutant eye tissue seen following generation of wild type non-ablating clones is moderately reduced at 25[o]C compared to 30[o]C suggesting the mutation is temperature sensitive. cmet[A1C5] mutant eyes show moderate growth defects when tissue is ablated during the larval stages using irradiation. (Gerhold et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	A1C5 (Gerhold et al., 2011) cmet^A1C5
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Gerhold et al., 2011, Genetics 189(4): 1309--1326 Identification and characterization of genes required for compensatory growth in Drosophila. [FBrf0217000]

Allele Dmel\cmetA1C5

Allele Dmel\cmet^A1C5