Eggs laid by homozygous females show a very low rate of hatching (0.7%). Most embryos laid by the mutant females show normal nuclear morphology until division 10, but after this stage defects in nuclear morphology begin to be seen. By division 13, less than one-third of the mutant embryos have normal nuclear morphology.
Homozygous animals show an increased frequency of generation of mutant clones compared to wild type in a loss of heterozygosity assay.
Ionising radiation-induced G2 arrest and apoptosis occur normally in homozygous eye discs.
Homozygous eye discs show defects in hydroxyurea-induced G2 arrest.
Homozygous larvae show reduced survival in the presence of hydroxyurea compared to wild type.