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General Information
Symbol
Dmel\Claspinaq5
Species
D. melanogaster
Name
FlyBase ID
FBal0277230
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Deletion resulting from the imprecise excision of P{EP}GE20270, extending from +4299 to +5195, where +1 is the translation start of Claspin.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion which removes part of the Claspin gene (nucleotides +4299 to +5195 relative to the transcription start site are removed).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs laid by homozygous females show a very low rate of hatching (0.7%). Most embryos laid by the mutant females show normal nuclear morphology until division 10, but after this stage defects in nuclear morphology begin to be seen. By division 13, less than one-third of the mutant embryos have normal nuclear morphology.

Homozygous animals show an increased frequency of generation of mutant clones compared to wild type in a loss of heterozygosity assay.

Ionising radiation-induced G2 arrest and apoptosis occur normally in homozygous eye discs.

Homozygous eye discs show defects in hydroxyurea-induced G2 arrest.

Homozygous larvae show reduced survival in the presence of hydroxyurea compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)