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General Information
Symbol
Dmel\CRMPsupIa1
Species
D. melanogaster
Name
FlyBase ID
FBal0277233
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

5381 bp deletion associated with the imprecise excision of P{EP}CRMPEP3238, which removes all of exons E1 through E9a of CRMP.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}CRMPEP3238 resulting in an intragenic deletion of 5380 bp (Genbank GU452678), removing all of exons E1 through E9a of CRMP which corresponds to the N-terminal 42% of the CRMP open reading frame.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous, hemizygous, or heteroallelic CRMPsupIa1 mutants are viable, fertile, and morphologically normal when grown under standard laboratory conditions.

When tested for short term memory performance 2 minutes after a single aversive Pavlovian training session, CRMPsupK1/CRMPsupIa1 as well as homozygous CRMPsupIa1 mutants exhibit significantly reduced performance compared with wild-type control flies. Medium-term memory performance measured 3 hours after a single aversive Pavlovian training session is also reduced in homozygous mutants and heteroallelic mutant animals.

Under free-running conditions (constant darkness), wild-type and CRMPsupIa1 mutant animals exhibit similar overall activity. Period length is similar for all tested animals, indicating that the length of the circadian clock is not affected by CRMPsupIa1. Compared with wild-type and heterozygous animals, significantly reduced arrhythmic power values indicating the relative strength of rhythmicity of free-running behaviours are observed among CRMPsupIa1/Df(3R)noi-B hemizygotes and CRMPsupK1/CRMPsupIa1 heteroallelic animals. Surprisingly, power values for CRMPsupIa1 homozygotes are not significantly reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)