|Feature type||allele||Associated gene||Dmel\psidin|
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Controlled Vocabulary Terms
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: K471@.
Amino acid replacement: ?471@.
|Phenotype Manifest In|
Homozygous olfactory receptor neuron (ORN) clones result in complete loss of the Or33c and Or42a-expressing ORNs and a mild reduction in cell number of the Or67d, Or22a and Or59c ORNs. Homozygous ORN clones result in defects in glomerulus targeting. Mutant Or59c ORNs show a strong mistargeting phenotype. Neurons in primary neuron cultures derived from mutant embryos have significantly smaller lamellipodia and significantly longer neurites compared to wild-type controls.
Homozygous border cells show defects in migration: many of the mutant cells show no migration at all, and more than 80% of mutant clusters fail to reach the oocyte by stage 10. Heterozygous border follicle cells have shorter actin-rich protrusions than controls.
|Phenotype Manifest In|
psidin55D4 has adult olfactory receptor neuron Or59c | somatic clone phenotype, suppressible | partially | somatic clone by Tm1ZCL0722
psidin55D4 has border follicle cell | somatic clone phenotype, suppressible | partially | somatic clone by Tm1ZCL0722
The reduction in lamellipodia size and increase in neurite length which is seen in neurons in primary neuron cultures derived from psidin[55D4] embryos are suppressed if the embryos are also mutant for Tm1[ZCL0722]. psidin[55D4] Tm1[ZCL0722] double mutant Or59c olfactory receptor neuron (ORNs) show a marked reduction in the penetrance and severity of axonal targeting defects compared to psidin[55D4] single mutant ORNs, but the reduction in the number of Or59c ORNs seen in psidin[55D4] single mutant ORNs is not rescued in the double mutants.
|Complementation & Rescue Data|
|Fails to complement|
Expression of psidin[Scer\UAS.cKa] under the control of Scer\GAL4[slbo.2.6] rescues the migration defects seen in homozygous psidin[55D4] border cells. Expression of psidin[Scer\UAS.cKa] under the control of Scer\GAL4[Act.PU] rescues the lethality of psidin[55D4]/psidin[85D1] animals.
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 2 )|