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General Information
Symbol
Dmel\mir-bftUAS.pLUC
Species
D. melanogaster
Name
FlyBase ID
FBal0277351
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Ppyr\LUC followed by a genomic fragment containing the bft pre-miRNA hairpin.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of bftScer\UAS.T:Ppyr\LUC driven by Scer\GAL4Myo31DF-NP0001 leads to a significant increase in the number of mitotic cells in the adult posterior midgut, as compared to controls.

bftΔ263a/bftΔ263a-G4 transheterozygotes expressing bftScer\UAS.T:Ppyr\LUC under the control of Scer\GAL4bft-Δ263a-G4, the inherent Gal4 driver in the bftΔ263a-G4 alele, where it replaces the bft hairpin sequence, present a significant increase in the thickness of the peritrophic matrix, as compared to controls.

Expression of bftScer\UAS.T:Ppyr\LUC under the control of Scer\GAL4sd-SG29.1 results in the wing consisting of a large blister. Hairs on the wing margin are irregular.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The expression of bftScer\UAS.T:Ppyr\LUC driven by Scer\GAL4bft-Δ263a-G4, the inherent Gal4 driver in the bftΔ263a-G4 alele, where it replaces the bft hairpin sequence, suppresses the overall increase in the gut pH, and suppresses both the increased number of mitotic cells and the decreased thickness of the peritrophic matrix in the posterior midgut of bftΔ263a/bftΔ263a-G4 transheterozygous mutant adults, even leading to a significant increase in the peritrophic matrix thickness as compared to wild-type controls.

The expression of bftScer\UAS.T:Ppyr\LUC driven by Scer\GAL4Myo31DF-NP0001 leads to an increase in the number of mitotic cells in the adult posterior midgut as compared to controls, but it does not significantly affect (it does not rescue or enhance) the increased number of mitotic cells observed in the adult posterior midgut of bftΔ263a homozygotes.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
bftScer\UAS.T:Ppyr\LUC
bftUAS.pLUC
mir-bftUAS.pLUC
Name Synonyms
Secondary FlyBase IDs
    References (2)