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General Information
Symbol
Dmel\pdm3UAS.long
Species
D. melanogaster
Name
FlyBase ID
FBal0277659
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-pdm3
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the long pdm3 splice form.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing pdm3UAS.long under the control of Scer\GAL4GMR22C07 in combination with Scer\GAL80[tsh-GAL80] (to inhibit expression in thoracic segments) induces axon misrouting in vtd2 neurons of abdominal segments 4-6 in third instar larvae. Unlike wild-type controls which innervate the ventral nerve cord, misexpressing vtd2 neurons project into the subesophageal ganglion (SEG), establishing presynaptic brp-positive sites along the way. Their significantly elongated axon is similar in length to wild-type pdm3-positive SEG-targeting vtd1 neurons of abdominal segments 4-6.

Expressing pdm3UAS.long under the control of Scer\GAL4ppk.PG induces axon targeting defects in class IV da neurons: defasciculation, axon wandering away from the ventral neuropil, and thinning of the axon scaffold near the midline. Some stray class IV da axons project anteriorly towards the SEG.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of pdm3Scer\UAS.long under the control of Scer\GAL4acj6-PG63 partially rescues the loss of odor response seen in pdm3f00828 mutant pb1A neurons. 7/29 pb1 sensilla show a response when tested with 3 odorants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
pdm3Scer\UAS.long
pdm3UAS.long
Name Synonyms
Secondary FlyBase IDs
    References (2)