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General Information
Symbol
Dmel\cazdsRNA.1-167.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0277712
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Caz-IR1-167
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat of sequence corresponding to part of the caz open reading frame (residues 1-167), arranged in head-to-head orientation.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Scer\GAL4GMR.PS>cazdsRNA.1-167.Scer\UAS in eye imaginal discs induces morphologically aberrant rough eyes. Scanning electron microscope (SEM) images show fusion of ommatidia and loss of mechanosensory bristles.

Knockdown of caz in all tissues, through expression of cazdsRNA.1-167.Scer\UAS under the control of Scer\GAL4Act5C.PI, results in late pupal lethality. Knockdown of caz in the developing eye, in the region posterior to the morphogenetic furrow, under the control of Scer\GAL4GMR.PS, induces morphologically aberrant rough eyes. SEM images show fusion of ommatidia and a lack of bristles.

Expression of cazdsRNA.1-167.Scer\UAS under the control of Scer\GAL4Act5C.PI results in pupal lethality at 28[o]C (all lines analysed), but results in viability at 25[o]C (for most lines analysed).

Flies expressing cazdsRNA.1-167.Scer\UAS under the control of Scer\GAL4elav.PLu show no significant difference in life span compared to control flies. The flies show reduced ability in a climbing assay compared to controls.

The total length of synaptic branches and the number of boutons at the neuromuscular junction are reduced compared to wild type in larvae expressing cazdsRNA.1-167.Scer\UAS under the control of Scer\GAL4elav.PLu, while bouton size is normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cazdsRNA.1-167.Scer\UAS
cazdsRNA.1-167.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)