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General Information
Symbol
Dmel\Dop1R1UAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0277733
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of Dop1R1 coding sequences starting from exon 2 onwards (i.e. from the first intron, thereby missing the first predicted translation start site).
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of DopRScer\UAS.cKa under the control of Scer\GAL4ey-OK107 in a homozygous DopRf02676 background (which will also result in the expression of DopR from the Scer\UAS regulatory sequences present in the insertion in DopRf02676) results in a severe defect in long-term olfactory memory measured 24 hours after spaced repetitive training.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Flies of the genotype Scer\GAL45.30/+; DopRf02676/DopRf02676 show selectively restored expression of DopR. Those flies that had restored expression in patterns that include the R2/R4 class ellipsoid body neurons exhibit rescue of ethanol-induced hyperactivity. Restoring DopR expression in the R3 neurons of the ellipsoid body neurons (through Scer\GAL4lilli-189Y) results in a modest but statistically significant increase in ethanol-induced hyperactivity. However, expression with Scer\GAL4Aph-4-c232 has no effect on ethanol induced hyperactivity in DopRf02676 homozygous mutants.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Dop1R1Scer\UAS.cKa
Dop1R1UAS.cKa
DopRScer\UAS.cKa
Name Synonyms
Secondary FlyBase IDs
    References (2)