Allele Dmel\parvin⁶⁹⁴

General Information
Symbol	Dmel\parvin⁶⁹⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0277792
Feature type	allele	Associated gene	Dmel\parvin

Allele class	amorphic allele - molecular evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - molecular evidence (Vakaloglou et al., 2012)
Mutagen	P-element activity (Vakaloglou et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}parvin^EY03677 (Vakaloglou et al., 2012)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a deletion of sequences encoding parvin amino acid residues 1-278. (Vakaloglou et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Vakaloglou et al., 2012)
Phenotype Manifest In

Detailed Description
	Statement Reference Mutants die at the late embryonic stage. F-actin is pulled away from the muscle attachment sites in the mutant stage 17 embryos. (Vakaloglou et al., 2012)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference parvin[694] ; Ilk[54] stck[T2] triple mutant embryos have actin clumps that are detached from the muscle attachment sites, as occurs in single mutant embryos. (Vakaloglou et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	parvin⁶⁹⁴ is rescued by parvin^{7.2.T:Avic\GFP} (Vakaloglou et al., 2012)
Partially rescued by	parvin⁶⁹⁴ is partially rescued by Scer\GAL4^how-24B/Scer\GAL4^how-24B/parvin^Scer\UAS.cVa (Vakaloglou et al., 2012)
Not rescued by	parvin⁶⁹⁴ is not rescued by parvin^{3.5.T:Avic\GFP} (Vakaloglou et al., 2012)
Comments	Expression of parvin[Scer\UAS.cVa] under the control of Scer\GAL4[how-24B] almost completely rescues the lethality of parvin[694] (90% of the expected adult flies are recovered). The rescued adults have blisters in both wings. (Vakaloglou et al., 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	parvin⁶⁹⁴ (Vakaloglou et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Vakaloglou et al., 2012, J. Cell Sci. 125(13): 3221--3232 Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development. [FBrf0219290]

Allele Dmel\parvin694

Allele Dmel\parvin⁶⁹⁴