|Feature type||allele||Associated gene||Dmel\dia|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - deletion, in vitro construct - coding region fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Expression of dia[FH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[en-e16E] results in the dynamic lamellipodia and filopodia of the leading edge cells being replaced by lamellipodia with ruffled edges and by fan-shaped lamellipodia with radial actin arrays not seen in wild-type lamellipodia. These lamellipodia are larger than in wild type. Filopodial number, length and lifetime are all significantly decreased compared to wild type. Many of the remaining "filopodia" arise from fan-shaped lamellipodia and do not grow substantially after their appearance, in contrast to wild-type filopodia.
|Phenotype Manifest In|
Scer\GAL4en-e16E, diaFH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP has embryonic leading edge cell phenotype, suppressible by Scer\GAL4en-e16E/Zzzz\actAFP4mito.Scer\UAS.T:Avic\GFP-EGFP
Scer\GAL4en-e16E, diaFH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP has filopodium phenotype, suppressible by Scer\GAL4en-e16E/Zzzz\actAFP4mito.Scer\UAS.T:Avic\GFP-EGFP
Scer\GAL4en-e16E, diaFH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP, enaScer\UAS.T:Avic\GFP has embryonic leading edge cell phenotype
Scer\GAL4en-e16E, diaFH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP, enaScer\UAS.T:Avic\GFP has filopodium phenotype
Co-expression of Zzzz\actA[FP4mito.Scer\UAS.T:Avic\GFP-EGFP] largely restores filopodia number and length to wild type in leading edge cells expressing dia[FH1FH2.Scer\UAS.P\T.T:Avic\GFP-EGFP] under the control of Scer\GAL4[en-e16E]. Fewer ruffle-like lamellipodia are seen and those that form are nearer wild type in size.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|