FB2025_01 , released February 20, 2025
Allele: BacA\p35UASp.cBa
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General Information
Symbol
BacA\p35UASp.cBa
Species
N. Autographa californica nucleopolyhedrovirus
Name
FlyBase ID
FBal0278239
Feature type
allele
Associated gene
BacA\p35
Associated Insertion(s)
Carried in Construct
P{UASp-p35.B}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Baum et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-p35.B}
Cytology
Description

UASp regulatory sequences drive expression of BacA:p35.

(Baum et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
BacA:p35
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eyes of female flies expressing BacA\p35Scer\UAS.P\T.cBa under the control of Scer\GAL4GMR.PF are 20% larger than wild type. No increase is seen in male flies.

      (Pechkovsky et al., 2013)

      Expression of BacA\p35Scer\UAS.P\T.cBa under the control of both Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16 results in defective egg chambers during mid-oogenesis (stages 7-9), characterised by a lack of follicle cells and the presence of large, uncondensed nurse cell nuclei. Approximately 20% of stage 14 egg chambers show uncondensed, persisting nurse cell nuclei.

      (Baum et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BacA\p35Scer\UAS.P\T.cBa partially rescues the eye phenotypes seen when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4GMR.PF at 24[o]C. In females the resulting eye size is comparable to wild type, whereas males eyes are ~85% the size of those in wild type flies. Eyes still appear rough and shape remains disrupted.

      Expression of BacA\p35Scer\UAS.P\T.cBa rescues the eye phenotypes seen when rprScer\UAS.cZa is expressed under the control of Scer\GAL4GMR.PF at 24[o]C. In females, eye size is increased compared to wild type (but is still small compared to the expression of BacA\p35Scer\UAS.P\T.cBa alone), whereas in males the eye size seen is comparable to that seen in wild type. Expression of BacA\p35Scer\UAS.P\T.cBa eliminates eye roughness in both males and females.

      Expression of BacA\p35Scer\UAS.P\T.cBa completely suppresses the lethality seen when rprScer\UAS.C is expressed under the control of Scer\GAL4GMR.PF at 24[o]C.

      (Pechkovsky et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BacA\p35Scer\UAS.P\T.cBa
      BacA\p35UASp.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)