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General Information
Symbol
Dmel\zipD1430N.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0278255
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G24993426A

Reported nucleotide change:

gat>aat

Amino acid change:

D1514N | zip-PA; D1469N | zip-PB; D1429N | zip-PC; D1474N | zip-PD; D1429N | zip-PE; D1437N | zip-PF; D1429N | zip-PG; D1437N | zip-PH; D1482N | zip-PI

Reported amino acid change:

D1430N

Comment:

Analogous D1424N mutation in human MYH-9 implicated in MYH-9 related disease; mutation carried on in vitro construct.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The amino acid replacement D1430N has been introduced into the zip coding region. This mutation corresponds to the disease-associated mutation D1424N in the orthologous human MYH9 gene.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying clones expressing zipD1430N.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4Act.PU in the Johnston's organ display detached scolopidia phenotype although its penetrance is low (around 5%).

zipD1430N.Scer\UAS.T:Avic\GFP (expressed using Scer\GAL4sqh.PW) does not show dominant negative activity in a zip1/+ background: the animals complete development and eclose as adult flies simultaneously with their wild-type siblings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Some adults expressing zipD1430N.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4en-e16E in a zip2/+ ; Rho1E3.10/+ background show both leg and wing abnormalities (11%), while others show wing abnormalities only (5.4%).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of zipD1430N.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4sqh.PW rescues the embryonic lethality of zip1/zip2 animals. 72 +/- 5% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
zipD1430N.Scer\UAS.T:Avic\GFP
zipD1430N.UAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (2)