Allele Dmel\zip^{D1847K.Scer\UAS.T:Avic\GFP}

General Information
Symbol	Dmel\zip^{D1847K.Scer\UAS.T:Avic\GFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0278256
Feature type	allele	Associated gene	Dmel\zip

Allele class
Mutagen	in vitro construct - amino acid replacement
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Franke et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	zip^{FL.Scer\UAS.T:Avic\GFP} (Franke et al., 2007)
Nature of the lesion	Statement Reference The amino acid replacement D1847K has been introduced into the zip coding region. This mutation corresponds to the disease-associated mutation E1841K in the orthologous human MYH9 gene. (Franke et al., 2007)
Carried in construct	P{UAS-zip.GFP.D1847K} (Franke et al., 2007)
Tagged with	T:Avic\GFP (Franke et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference zip[D1847K.Scer\UAS.T:Avic\GFP] (expressed using Scer\GAL4[sqh.PW]) does not show dominant negative activity in a zip[1]/+ background: the animals complete development and eclose as adult flies simultaneously with their wild-type siblings. (Franke et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Rho1^E3.10/Rho1[+], Scer\GAL4^en-e16E, zip², zip^{D1847K.Scer\UAS.T:Avic\GFP} has visible phenotype (Franke et al., 2007)
Phenotype Manifest In
Other
Statement Reference Rho1^E3.10/Rho1[+], Scer\GAL4^en-e16E, zip², zip^{D1847K.Scer\UAS.T:Avic\GFP} has leg phenotype (Franke et al., 2007) Rho1^E3.10/Rho1[+], Scer\GAL4^en-e16E, zip², zip^{D1847K.Scer\UAS.T:Avic\GFP} has wing phenotype (Franke et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Some adults expressing zip[D1847K.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E] in a zip[2]/+ ; Rho1[E3.10]/+ background show both leg and wing abnormalities (8.2%). (Franke et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	zip^{D1847K.Scer\UAS.T:Avic\GFP}/Scer\GAL4^sqh.PW partially rescues zip²/zip¹ (Franke et al., 2007)
Comments	Expression of zip[D1847K.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[sqh.PW] rescues the embryonic lethality of zip[1]/zip[2] animals. 85 +/- 12% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage. (Franke et al., 2007)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	zip^{D1847K.Scer\UAS.T:Avic\GFP}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Franke et al., 2007, Hum. Mol. Genet. 16(24): 3160--3173 An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. [FBrf0201204]

Allele Dmel\zipD1847K.Scer\UAS.T:Avic\GFP

Allele Dmel\zip^{D1847K.Scer\UAS.T:Avic\GFP}