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General Information
Symbol
Dmel\Atg8ad4
Species
D. melanogaster
Name
FlyBase ID
FBal0278389
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Atg8a[d4]
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Deletion resulting from the imprecise excsion of P{SUPor-P}Atg8aKG07569, which removes the first 25 aa of Atg8a and the first 53 aa of BTBD9.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of P{SUPor-P}Atg8aKG07569 removes the first 25 codons of Atg8a and the first 53 codons of BTBD9.
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Atg8ad4 mutant adults do not display any obvious eye morphology defects or signs of degeneration.
Atg8ad4 homozygous mutants do not show any obvious defects in the morphology or structure of the adult thorax or loss of thoracic muscles.
Df(1)Atg8ad4 mutants are homozygous viable and fertile with no gross morphological or developmental abnormalities.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
scrib673-homozygous, Ras85DV12.Scer\UAS-expressing tumors grow to significantly smaller sizes when grafted into the abdomen of Atg8ad4 homozygous adult hosts, as compared to control hosts.
Xenogenetic Interactions
Statement
Reference
The eye degeneration induced by Hsap\FUSScer\UAS.cIa expression (one copy) under Scer\GAL4GMR.PS is not exacerbated by combination with Atg8ad4/+ and the eye defects in the Scer\GAL4GMR.PS/Atg8ad4;Hsap\FUSScer\UAS.cIa/+ flies can still be rescued by expression of lncRNA:HsrωdsRNA.Sym.Scer\UAS (one copy).
Expression of Hsap\MAPTScer\UAS.T:Avic\GFP in Atg8ad4 heterozygous background does not produce any obvious phenotype in the adult thorax. However, when Hsap\MAPTScer\UAS.T:Avic\GFP is expressed in either htt98E2/+;Atg8ad4/+ double heterozygotes or Atg8ad4 homozygotes nearly all the adult flies have collapsed thoraces and display loss of skeletal thoracic muscles.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)