FlyBase Allele Report: Dmel\Cyfip[HMS01754]

General Information

Symbol

Dmel\Cyfip^HMS01754

Species

D. melanogaster

Name

FlyBase ID

FBal0278872

Feature type

allele

Associated gene

Dmel\Cyfip

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01754}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01754}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01754

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant intellectual developmental disorder 48

modeled by Rac1^Y64D.UAS

(Banka et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | oogenesis, with Scer\GAL4^GR1

(Squarr et al., 2016)

Phenotype Manifest In

actin-based cell projection | oogenesis, with Scer\GAL4^GR1

(Squarr et al., 2016)

centripetal follicle cell, with Scer\GAL4^GR1

(Squarr et al., 2016)

egg | maternal effect, with Scer\GAL4^GR1

(Squarr et al., 2016)

egg | maternal effect, with Scer\GAL4^tj.PU

(Squarr et al., 2016)

egg chamber, with Scer\GAL4^GR1

(Squarr et al., 2016)

filopodium | oogenesis, with Scer\GAL4^GR1

(Squarr et al., 2016)

Detailed Description

Statement

Reference

Expression of Sra-1^HMS01754 under the control of Scer\GAL4^GR1 during oogenesis leads to complete loss of filopodia and junctional whip-like protrusions of migrating follicle cells, and completely abolishes egg chamber rotation, in contrast to wild type. Females expressing Sra-1^HMS01754 under the control of Scer\GAL4^GR1, or under the control of Scer\GAL4^tj.PU along with a Dicer-2 transgene to increase RNAi efficiency, lay abnormally round eggs.

(Squarr et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cyfip^HMS01754, Scer\GAL4^ppk.PG is a suppressor of abnormal neuroanatomy | larval stage phenotype of Rac1^Y64D.UAS, Scer\GAL4^ppk.PG

(Banka et al., 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cyfip^HMS01754, Scer\GAL4^ppk.PG is a suppressor of larval multidendritic class IV neuron | larval stage phenotype of Rac1^Y64D.UAS, Scer\GAL4^ppk.PG

(Banka et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38294

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01754}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cyfip^HMS01754

Sra-1^HMS01754

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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