Expression of domHMS01855 under the control of Scer\GAL4bbg-C96 results in a majority of flies exhibiting wing nicks, and some showing defective wing margins, in contrast to controls.
Expression of domHMS01855 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4otu.T:Hsim\VP16 causes significantly decreased female fertility, as compared to controls.
Expression of domHMS01855 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in a significant reduction in egg-laying, as compared to controls.
Expression of domHMS01855 under the control of Scer\GAL4tj.PU or Scer\GAL4C587 leads to severe packaging defects during oogenesis, ranging from two cysts in a single egg chamber to complete ovariole fusions; many germaria show additional stalk-like structures without germline cysts, and egg laying is nearly completely abolished, as compared to controls.