Expression of dom^HMS01855 under the control of Scer\GAL4^bbg-C96 results in a majority of flies exhibiting wing nicks, and some showing defective wing margins, in contrast to controls. Expression of dom^HMS01855 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{otu.T:Hsim\VP16} causes significantly decreased female fertility, as compared to controls. Expression of dom^HMS01855 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in a significant reduction in egg-laying, as compared to controls. Expression of dom^HMS01855 under the control of Scer\GAL4^tj.PU or Scer\GAL4^C587 leads to severe packaging defects during oogenesis, ranging from two cysts in a single egg chamber to complete ovariole fusions; many germaria show additional stalk-like structures without germline cysts, and egg laying is nearly completely abolished, as compared to controls.

(Börner and Becker, 2016)