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General Information
Symbol
Dmel\dlg1HMS01954
Species
D. melanogaster
Name
FlyBase ID
FBal0279068
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a short inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The expression of dlg1HMS01954 driven by Scer\GAL4Bx-MS1096 leads to the formation of tumors in the third instar larval wing disc, with overgrowth, tissue disorganization and expansion of the apical cortical domain, as compared to controls.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The co-expression of dlg1HMS01954 and pnutGD1512 from the second instar larval stage under the combined control of Scer\GAL4ap-md544 and Gal80[ts] does not leads to the formation of tumors in the third instar larval wing disc.
The tumor phenotype and tissue disorganization resulting from the expression of dlg1HMS01954 under the control of Scer\GAL4Bx-MS1096 is fully or partially suppressed by the co-expression of vgScer\UAS.cKa, bskK53R.Scer\UAS, kaypan-Ala.Scer\UAS or brmK804R.Scer\UAS.T:Ivir\HA1, but not by the co-expression of CatScer\UAS.cAa. The co-expression of eyScer\UAS.cHa in third instar larval wing discs already expressing dlg1HMS01954 under the control of Scer\GAL4Bx-MS1096 does not suppress the tumor overgrowth, but induces ectopic photoreceptor formation in a small proportion of cells, as compared to controls.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
dlg1HMS01954
Name Synonyms
Secondary FlyBase IDs
    References (3)