FB2025_01 , released February 20, 2025
Allele: Dmel\HemK2HMS02003
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General Information
Symbol
Dmel\HemK2HMS02003
Species
D. melanogaster
Name
FlyBase ID
FBal0279116
Feature type
allele
Associated gene
Dmel\HemK2
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS02003}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS02003}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS02003
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HemK2HMS02003 under the control of Scer\GAL4esg-NP5130 combined with Gal80[ts] to bypass the developmental stage and Scer\GAL80Su(H).GBE to limit the expression to intestinal stem cells (ISCs) has no significant effect on the number of ISCs, but it significantly reduced the number of actively proliferating (EdU+) cells in the posterior adult midgut (similar reduction is also observed without the addition of Scer\GAL80Su(H).GBE).

      (Obata et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has female sterile phenotype, suppressible by BacA\p35UASp.cWa, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has decreased fecundity phenotype, suppressible | partially by BacA\p35UASp.cWa, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has female sterile phenotype, suppressible by p53HMS02286, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has decreased fecundity phenotype, suppressible | partially by p53HMS02286, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has decreased fecundity phenotype, suppressible | partially by Ski8HMC04664, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has female sterile phenotype, suppressible by Ski8HMC04664, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has decreased fecundity phenotype, suppressible | partially by peloRNAi.UAS.cXa, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)

      HemK2HMS02003, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG has female sterile phenotype, suppressible by peloRNAi.UAS.cXa, Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG

      (Xu et al., 2024)
      NOT suppressed by
      Other
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG9960HMS02003
      HemK2HMS02003
      Name Synonyms
      Secondary FlyBase IDs
        References (3)