Expression of dom^HMS02162 under the control of Scer\GAL4^Act5C.PI results in pupal lethality.

Expression of dom^HMS02162 under the control of Scer\GAL4^bbg-C96 results in a majority of flies exhibiting wing nicks, and some showing defective wing margins, in contrast to controls.

Expression of dom^HMS02162 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{otu.T:Hsim\VP16} causes significantly decreased female fertility, small ovaries and defects in cyst differentiation in the germarium, as compared to controls.

Expression of dom^HMS02162 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} does not affect the development of the germarium or ovariole, but results in significant proportion of eggs showing the 'dumpless' egg phenotype, as shown by defective late stage egg chambers with short eggs and non-fragmented nurse cells, and a significant reduction in egg-laying, as compared to controls.

Expression of dom^HMS02162 under the control of Scer\GAL4^tj.PU or Scer\GAL4^C587 leads to severe packaging defects during oogenesis, ranging from two cysts in a single egg chamber to complete ovariole fusions; many germaria show additional stalk-like structures without germline cysts, and egg laying is nearly completely abolished, as compared to controls.