FlyBase Allele Report: Dmel\p53[HMS02286]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\p53^HMS02286

General Information

Symbol

Dmel\p53^HMS02286

Species

D. melanogaster

Name

FlyBase ID

FBal0279287

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02286}

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02286}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Maor-Nof et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

p53^HMS02286, Scer\GAL4^nanos.PG, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female sterile phenotype of HemK2^HMS02003, Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

(Xu et al., 2024)

p53^HMS02286, Scer\GAL4^nanos.PG, Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of decreased fecundity phenotype of HemK2^HMS02003, Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

(Xu et al., 2024)

Phenotype Manifest In

Suppressor of

Statement

Reference

p53^HMS02286, Scer\GAL4^nanos.PG, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of egg chamber phenotype of HemK2^HMS02003, Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

(Xu et al., 2024)

NOT Suppressor of

Statement

Reference

p53^HMS02286, Scer\GAL4^nanos.PG, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of nurse cell phenotype of HemK2^HMS02003, Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^nanos.PG

(Xu et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

605587

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02286}attP2

HMS02286

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02286}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

p53^HMS02286

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections