FlyBase Allele Report: Dmel\sbr[HMS02414]

General Information

Symbol

Dmel\sbr^HMS02414

Species

D. melanogaster

Name

FlyBase ID

FBal0279411

Feature type

allele

Associated gene

Dmel\sbr

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02414}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02414}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02414

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^VP16.otu

(Yan and Perrimon, 2015)

lethal | female limited, with Scer\GAL4^dome-PG14

(Yan and Perrimon, 2015)

short lived, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

visible, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

Phenotype Manifest In

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

wing, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

Detailed Description

Statement

Reference

Adult flies expressing sbr^HMS02414 under the control of Scer\GAL4^Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

(Fu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

sbr^HMS02414, Scer\GAL4^dpp.PU is a non-enhancer of increased cell growth rate | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

sbr^HMS02414, Scer\GAL4^dpp.PU is a non-enhancer of eye-antennal disc | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^dpp.PU

(Snee et al., 2016)

sbr^HMS02414, Scer\GAL4^dpp.PU is a non-enhancer of wing disc | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of sbr^HMS02414 does not enhance tissue overgrowth in eye-antennal imaginal or wing discs with expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^dpp.PU or Scer\GAL4^Bx-MS1096.

(Snee et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

42013

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02414}attP40

NIG-Fly

HMS02414

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02414}attP40/CyO

Notes on Origin

Discoverer

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sbr^HMS02414

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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