Allele Dmel\hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Dmel\hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0279496
Feature type	allele	Associated gene	Dmel\hpo

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion, in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Jin et al., 2012) in vitro construct - coding region fusion (Jin et al., 2012) in vitro construct - regulatory fusion (Jin et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of a mutated form of hpo containing the amino acid replacement M242E. The protein is tagged with T:Zzzz\FLAG. (Jin et al., 2012)
Carried in construct	P{UAS-hpo.M242E.FLAG} (Jin et al., 2012)
Tagged with	T:Zzzz\FLAG (Jin et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^Bx-MS1096 (Jin et al., 2012)
Phenotype Manifest In
	wing, with Scer\GAL4^Bx-MS1096 (Jin et al., 2012)
Detailed Description
	Statement Reference Expression of hpo[M242E.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[Bx-MS1096] results in a slight increase in wing size compared to controls. (Jin et al., 2012)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}/Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Scer\GAL4^GMR.PU, yki^Scer\UAS.cZa (Jin et al., 2012)
Phenotype Manifest In
Enhancer of
Statement Reference hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, yki^Scer\UAS.cZa (Jin et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of hpo[M242E.Scer\UAS.T:Zzzz\FLAG] enhances the eye overgrowth phenotype caused by expression of yki[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PU]. (Jin et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	Scer\GAL4^tub.PU/hpo^{M242E.Scer\UAS.T:Zzzz\FLAG} partially rescues hpo^BF33 (Jin et al., 2012)
Comments	Expression of hpo[M242E.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[tub.PU] partially rescues the overgrowth phenotype caused by hpo[BF33] clones in the eye. (Jin et al., 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Jin et al., 2012, J. Biol. Chem. 287(8): 5784--5796 Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. [FBrf0217990]

Allele Dmel\hpoM242E.Scer\UAS.T:Zzzz\FLAG

Allele Dmel\hpo^{M242E.Scer\UAS.T:Zzzz\FLAG}