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General Information
Symbol
Dmel\Cdk5Δ
Species
D. melanogaster
Name
FlyBase ID
FBal0279520
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Genomic fragment from clone BACR48C01 in which an internal DraIII fragment corresponding to the 5' part of Cdk5 has been deleted. The fragment contains the complete Flo-1, CG30466 and CG8204 genes and the 3'UTR of Cdk5.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}) are viable and fertile and have no evident morphological defects. Circadian rhythm of these animals is normal, but they show reduced flight ability compared to wild type. The adults have locomotor defects, including a higher rate of falling from the culture vial wall than wild type and an inability to right themselves after falling on their back. Mutant larvae show synaptic overgrowth at the neuromuscular junction. The number of boutons per muscle area is increased compared to wild type and the boutons are smaller than normal. The miniature (mEJC) and evoked (eEJC) postsynaptic currents have normal amplitude and frequency in these larvae.

Flies lacking Cdk5 function (Df(2R)Exel9026/Df(2R)ED2426 animals with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}) are viable and fertile and have no evident morphological defects. Circadian rhythm of these animals is normal, but they show reduced flight ability compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The synaptic overgrowth phenotype at the neuromuscular junction seen in third instar larvae lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}) is not altered if the larvae are also homozygous or futschK68.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Cdk5+tKa rescues the locomotor and flight defects of adults lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

Cdk5+tKa rescues the synaptic overgrowth at the neuromuscular junction seen in third instar larvae lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

Cdk5+tKa rescues the flight defects of adults lacking Cdk5 function (Df(2R)Exel9026/Df(2R)ED2426 animals with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Cdk5Δ
Name Synonyms
Secondary FlyBase IDs
    References (1)