FB2025_01 , released February 20, 2025
Allele: Dmel\Cdk5+tKa
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General Information
Symbol
Dmel\Cdk5+tKa
Species
D. melanogaster
Name
FlyBase ID
FBal0279521
Feature type
allele
Associated gene
Dmel\Cdk5
Associated Insertion(s)
Carried in Construct
P{Cdk5wt}
Key Links
Transgenic product class
genomic_DNA
(Kissler et al., 2009)
wild_type
(Kissler et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Kissler et al., 2009)
wild_type
(Kissler et al., 2009)
Mutagen
in vitro construct
(Kissler et al., 2009)
Progenitor genotype
Carried in construct
P{Cdk5wt}
Cytology
Description

Genomic EcoRI fragment containing the complete Cdk5 transcription unit.

(Kissler et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
Cdk5
Encoded product / tool
Cdk5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Cdk5+tKa rescues the locomotor and flight defects of adults lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

      Cdk5+tKa rescues the synaptic overgrowth at the neuromuscular junction seen in third instar larvae lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

      Cdk5+tKa rescues the flight defects of adults lacking Cdk5 function (Df(2R)Exel9026/Df(2R)ED2426 animals with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}).

      The synaptic overgrowth at the neuromuscular junction seen in third instar larvae lacking Cdk5 function (Df(2R)Exel9026 homozygotes with all deleted gene functions except Cdk5 restored using P{Flo-1wt.Cdk5Δ.CG30466wt.CG8204wt}) is rescued by expression of Cdk5Scer\UAS.P\T.cKa under the control of either Scer\GAL4D42 or Scer\GAL4elav.PLu but is not rescued by expression under the control of Scer\GAL4Mhc.PW.

      (Kissler et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cdk5+tKa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)