FB2025_01 , released February 20, 2025
Allele: Dmel\tkvS238A.ca.bam
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General Information
Symbol
Dmel\tkvS238A.ca.bam
Species
D. melanogaster
Name
FlyBase ID
FBal0279567
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{bam-tkv.ca.S238A}
Key Links
Transgenic product class
missense_variant
(Xia et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Xia et al., 2010)
Mutagen
in vitro construct
(Xia et al., 2010)
Progenitor genotype
tkvca.UASp
(Xia et al., 2010)
Carried in construct
P{bam-tkv.ca.S238A}
Cytology
Description

The bam promoter drives expression of a constitutively active form of tkv (in which the glutamine at amino acid 253 has been replaced with aspartic acid). The serine at amino acid 238 has been replaced by alanine.

(Xia et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
bam
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tkvS238A.ca.bam results in germaria that contain an increased number of spectrosome-containing GSC-like cells.

      (Xia et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tkvS238A.ca.bam
      Name Synonyms
      Secondary FlyBase IDs
        References (1)