FlyBase Allele Report: Dmel\CG31687[GD10330]

General Information

Symbol

Dmel\CG31687^GD10330

Species

D. melanogaster

Name

FlyBase ID

FBal0280136

Feature type

allele

Associated gene

Dmel\CG31687

Associated Insertion(s)

Carried in Construct

P{GD10330}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Weber et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Weber et al., 2012)

Mutagen

in vitro construct

(Weber et al., 2012)

Progenitor genotype

Carried in construct

P{GD10330}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Weber et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD10330

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Weber et al., 2012)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible | adult stage, with Scer\GAL4^GMR.PU

(Martins et al., 2017)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Martins et al., 2017)

ommatidium, with Scer\GAL4^hs.2sev

(Weber et al., 2012)

wing hair, with Scer\GAL4^en-e16E

(Weber et al., 2012)

wing hair | increased number, with Scer\GAL4^ap-md544

(Weber et al., 2012)

wing hair | increased number, with Scer\GAL4^dpp.blk1

(Weber et al., 2012)

Detailed Description

Statement

Reference

The expression of CG31687^GD10330 under the control of Scer\GAL4^GMR.PU Scer\GAL4^GMR.PU leads to a noticeable roughness in some eye patches, as compared to controls; expression under the control of Scer\GAL4^ey.PU does not lead to any obvious eye defects, as compared to controls.

(Martins et al., 2017)

Expression of fwd^GD12100 using Scer\GAL4^hs.2sev results in ommatidial planar cell polarity (PCP)-abnormalities in the eye.

Expression of CG31687^GD10330 under the control of Scer\GAL4^dpp.blk1 results in multiple cellular hairs in the wing.

Expression of CG31687^GD10330 under the control of Scer\GAL4^en-e16E results in wing hair orientation defects.

Expression of CG31687^GD10330 under the control of Scer\GAL4^ap-md544 results in multiple cellular hairs in the wing.

(Weber et al., 2012)

Adults expressing CG31687^GD10330 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CG31687^GD10330, Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

CG31687^GD10330, Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS