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General Information
Symbol
Dmel\TieDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0280304
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a dominant negative form of Tie which contains the signal sequence and extracellular and transmembrane domains, but lacks the intracellular kinase domain.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TieDN.Scer\UAS under the control of Scer\GAL4slbo.2.6 does not significantly alter the protrusion and retraction morphodynamics in border cell cluster migration.

Expression of TieDN.Scer\UAS under the control of Scer\GAL4c306 does not result in defects in border follicle cell migration.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The addition of a dominant-negative TieDN.Scer\UAS to border cells expressing PvrDN.Scer\UAS and EgfrDN.Scer\UAS alters the protrusion and retraction morphodynamics of border cell cluster migration.

Co-expression of TieDN.Scer\UAS enhances the border cell migration defects caused by expression of PvrDN.Scer\UAS under the control of Scer\GAL4slbo.2.6, such that 37-58% of stage 10 egg chambers show border cell migration defects.

Co-expression of PvrDN.Scer\UAS and EgfrDN.Scer\UAS under the control of Scer\GAL4c306 results in border cell migration defects. The severity of the migration defects is enhanced if the females also express TieDN.Scer\UAS.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
TieDN.Scer\UAS
TieDN.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)