S413A | eya-PA; S407A | eya-PB; S323A | eya-PC
Carried on a trangenic construct. Mutation of codon S407 (TCG) to Ala (GCG).
S408A | eya-PA; S402A | eya-PB; S318A | eya-PC
Carried on a trangenic construct. Mutation of codons S402 (TCC) to Asp (GCC).
One copy of eyaSA.GR rescues eye formation in eya2 homozygotes. The external morphology of the eyes are indistinguishable from wild type and cross sections show a normal number and arrangement of photoreceptors.
One copy of eyaSA.GR fully rescues the lethality of eyacli-IID/Df(2L)BSC354 animals. The rescued adults have eyes which are indistinguishable from wild type (both externally and in cross sections) and eye discs from late third instar larvae also appear normal. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults and third instar larvae appear normal. Rescued females are fertile and rescued males produce wild-type numbers of progeny when mated to wild-type virgin females.