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General Information
Symbol
Dmel\eyaSA.GR
Species
D. melanogaster
Name
FlyBase ID
FBal0281735
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T6529212G

Reported nucleotide change:

T?G

Amino acid change:

S413A | eya-PA; S407A | eya-PB; S323A | eya-PC

Reported amino acid change:

S407A

Comment:

Carried on a trangenic construct. Mutation of codon S407 (TCG) to Ala (GCG).

point mutation
Nucleotide change:

T6529227G

Reported nucleotide change:

T?G

Amino acid change:

S408A | eya-PA; S402A | eya-PB; S318A | eya-PC

Reported amino acid change:

S402A

Comment:

Carried on a trangenic construct. Mutation of codons S402 (TCC) to Asp (GCC).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Codons S402 and S407 (TCC and TCG respectively) in the eya coding region have been mutated to Ala residues (GCC and GCG respectively). This results in a non-phosphorylatable form of eya.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

One copy of eyaSA.GR rescues eye formation in eya2 homozygotes. The external morphology of the eyes are indistinguishable from wild type and cross sections show a normal number and arrangement of photoreceptors.

One copy of eyaSA.GR fully rescues the lethality of eyacli-IID/Df(2L)BSC354 animals. The rescued adults have eyes which are indistinguishable from wild type (both externally and in cross sections) and eye discs from late third instar larvae also appear normal. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults and third instar larvae appear normal. Rescued females are fertile and rescued males produce wild-type numbers of progeny when mated to wild-type virgin females.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
eyaSA.GR
Name Synonyms
Secondary FlyBase IDs
    References (1)