FB2025_01 , released February 20, 2025
Allele: Mmus\Dlk1SM.UAS
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General Information
Symbol
Mmus\Dlk1SM.UAS
Species
M. musculus
Name
FlyBase ID
FBal0282543
Feature type
allele
Associated gene
Mmus\Dlk1
Associated Insertion(s)
Carried in Construct
P{UAS-Dlk1.SM}
Transgenic product class
wild_type
(Bray et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bray et al., 2008)
Mutagen
in vitro construct
(Bray et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Dlk1.SM}
Cytology
Description

UASt regulatory sequences drive expression of full length Mmus\Dlk1, including the proteolytic cleavage site.

(Bray et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Dlk1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of one copy of Mmus\Dlk1SM.Scer\UAS under the control of Scer\GAL4ptc-559.1 results in occasional scutellar bristle duplications, and this phenotype is more penetrant with two copies of the transgene. Occasional wings have wing notching. Both of these effects are considerably enhanced at 30[o]C. Fewer cells are seen between L3 and L4 wing veins, and these cells are larger than normal. Cell number is further reduced upon expression of two copies of Mmus\Dlk1SM.Scer\UAS. In the larval wing disc, an increased number of sens-positive sensory-organ precursors is seen in the clusters that go on to form the chordotonal sensory organs of the dorsal and ventral radius.

      (Bray et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has visible | adult stage phenotype, enhanceable by N[+]/N55e11

      (Bray et al., 2008)
      NOT Enhanced by
      Statement
      Reference

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has decreased cell number | adult stage phenotype, non-enhanceable by N[+]/N55e11

      (Bray et al., 2008)

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has increased cell size | adult stage phenotype, non-enhanceable by N[+]/N55e11

      (Bray et al., 2008)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has wing phenotype, enhanceable by N[+]/N55e11

      (Bray et al., 2008)

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has scutellar bristle | ectopic phenotype, enhanceable by N[+]/N55e11

      (Bray et al., 2008)
      NOT Enhanced by
      Statement
      Reference

      Mmus\Dlk1SM.UAS, Scer\GAL4ptc-559.1 has wing cell phenotype, non-enhanceable by N[+]/N55e11

      (Bray et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of N55e11 enhances the wing notching and ectopic bristle phenotypes seen when Mmus\Dlk1SM.Scer\UAS is expressed under the control of Scer\GAL4ptc-559.1 at 25[o]C. Neither the decrease in number nor the increase in size of the cells between the L3 and L4 wing veins shows any enhancement.

      (Bray et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Dlk1SM.Scer\UAS
      Mmus\Dlk1SM.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)