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General Information
Symbol
Dmel\ATP6AP2Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0282679
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a 860bp deletion in VhaM8.9 which remove the first two exons.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ATP6AP2Δ1 homozygotes bearing ATP6AP2L98S or ATP6AP2ΔKKxx display severe mortality during the pupal stage; the surviving adults display poor mobility, decreased or absent climbing capabilities, blistered wings, and reduced head size, and die 3 to 4 days after eclosion, as compared to controls. ATP6AP2Δ1 homozygotes bearing ATP6AP2+t2.6 or ATP6AP2AxxA are viable.

ATP6AP2Δ1 homozygous third instar larvae bearing ATP6AP2L98S display a severe increases in the number of both optic lobe neuroblasts and of both optic lobe and central brain neurons (during mid-to-late third instar), and display a severe increase in the size of fat body lipid droplets, as compared to controls. In a ATP6AP2Δ1-homozygous background, ATP6AP2L98S clones exhibit significant increases in the size of lipid droplets and in the number of autophagosomes/lysosomes (identified as Lysotracker-positive or Atg8a-positive puncta) in the third instar larval fat body, as compared to neighboring ATP6AP2T:Hsap\MYC clones.

Homozygous clones result in planar cell polarity phenotypes which are generally stronger in the pupal than in the adult stages. In the pupal wing, a significant delay in prehair formation and an occasional multiple wing hair phenotype are seen. In the adult, hair and bristle polarity defects are seen in the adult wing and notum respectively.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
ATP6AP2Δ1
VhaM8.9Δ1
Name Synonyms
Secondary FlyBase IDs
    References (3)