Open Close
General Information
Symbol
Dmel\GgaΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0283002
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Ends-out gene targeting has resulted in 1131bp of Gga sequence (including 536bp of the third exon, the entire third intron and 526bp of the fourth exon) being replaced by a mini-w marker. This results in the loss of 353 codons.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

1131bp of Gga sequence (including 536bp of the third exon, the entire third intron and 526bp of the fourth exon) has been replaced by sequence encoding EYFP and a mini-w marker. This results in the loss of 353 Gga codons, including the C-terminal half of the VHS domain, the entire GAT domain and the N-terminal half of the hinge domain.

Insertion components
TI{TI}GgaΔ
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies show no evidence of age-dependent retinal degeneration at 2 weeks of age.

Mutant flies are hypersensitive to dietary chloroquine compared to wild-type controls.

Mutant flies are hypersensitive to amino acid starvation compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

GgaΔ is an enhancer of eye phenotype of Scer\GAL4GMR.PU, bchsEP2299

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Gga+t4.5 rescues the hypersensitivity to dietary chloroquine and hypersensitivity to amino acid starvation which is seen in GgaΔ flies.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
GgaΔ
Name Synonyms
Secondary FlyBase IDs
    References (1)