FlyBase Allele Report: Dmel\Crag[A]

General Information

Symbol

Dmel\Crag^A

Species

D. melanogaster

Name

FlyBase ID

FBal0283007

Feature type

allele

Associated gene

Dmel\Crag

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Xiong et al., 2012)

Mutagen

ethyl methanesulfonate

(Yamamoto et al., 2013-, Xiong et al., 2012)

Progenitor genotype

Cytology

Description

Amino acid replacement: C1372S.

(Xiong et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:8,599,591..8,599,591 [+]

Nucleotide change:

T8599591A

Amino acid change:

C1372S | Crag-PA; C1345S | Crag-PB; C1372S | Crag-PD

Reported amino acid change:

C1372S

Comment:

T to A nucleotide change at the first position or a G to C change at the second position of the Cys codon leads to a Ser (exact site of mutation unspecified). The mutation has been annotated at the first nucleotide of the codon.

(Xiong et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The electroretinograms of 3 week old flies containing homozygous clones in the eye (generated using the eyFLP method) show a reduction in both the amplitude of depolarization and the size of the "on" and "off" transients compared to wild type.

(Xiong et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Crag^A has lethal phenotype, suppressible by Hsap\DENND4A^UAS.cXa/Scer\GAL4^da.G32

(Xiong et al., 2012)

Other