FlyBase Allele Report: Dmel\Trap1[UAS.cCa]

General Information

Symbol

Dmel\Trap1^UAS.cCa

Species

D. melanogaster

Name

FlyBase ID

FBal0283027

Feature type

allele

Associated gene

Dmel\Trap1

Associated Insertion(s)

Carried in Construct

P{UAS-Trap1.C}

Key Links

Transgenic product class

wild_type

(Costa et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Costa et al., 2013)

Mutagen

in vitro construct

(Costa et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-Trap1.C}

Cytology

Description

UASt regulatory sequences drive expression of Trap1.

(Costa et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Trap1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Costa et al., 2013)

modeled by park²⁵

(Costa et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^da.G32

(Costa et al., 2013)

abnormal oxidative stress response, with Scer\GAL4^da.G32

(Costa et al., 2013)

chemical resistant, with Scer\GAL4^da.G32

(Costa et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^da.G32 results in significantly enhanced climbing performance in aged flies compared to controls.

Flies expressing Trap1^Scer\UAS.cCa under the control of Scer\GAL4^da.G32 have a normal lifespan. The flies show increased resistance to paraquat compared to controls.

(Costa et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PU/Trap1^UAS.cCa is a suppressor of visible phenotype of park²⁵

(Costa et al., 2013)

Scer\GAL4^Act5C.PU/Trap1^UAS.cCa is a suppressor of short lived phenotype of park²⁵

(Costa et al., 2013)

Scer\GAL4^Act5C.PU/Trap1^UAS.cCa is a suppressor of abnormal oxidative stress response | adult stage phenotype of park²⁵

(Costa et al., 2013)

Scer\GAL4^da.G32/Trap1^UAS.cCa is a suppressor of short lived phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^da.G32/Trap1^UAS.cCa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^da.G32/Trap1^UAS.cCa is a suppressor | partially of visible phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^elav.PU/Trap1^UAS.cCa is a suppressor | partially of visible phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^elav.PU/Trap1^UAS.cCa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Costa et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PU/Trap1^UAS.cCa is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Costa et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Trap1^UAS.cCa is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^Act5C.PU/Trap1^UAS.cCa is a suppressor of adult thorax phenotype of park²⁵

(Costa et al., 2013)

Scer\GAL4^da.G32/Trap1^UAS.cCa is a suppressor | partially of mitochondrion phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^elav.PU/Trap1^UAS.cCa is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Costa et al., 2013)

Scer\GAL4^elav.PU/Trap1^UAS.cCa is a suppressor | partially of mitochondrion phenotype of Pink1^B9

(Costa et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Trap1^Scer\UAS.cCa under the control of either Scer\GAL4^da.G32 or Scer\GAL4^elav.PU partially suppresses the thoracic indentation phenotype which is seen in Pink1^B9 flies.

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^da.G32 in Pink1^B9 flies improves their climbing ability, lifespan, resistance to paraquat and mitochondrial function.

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^elav.PU improves climbing ability and mitochondrial respiration in Pink1^B9 flies.

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^Act5C.PU partially suppresses the thoracic indentation phenotype which is seen in park²⁵ flies.

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^Act5C.PU does not rescue the impaired climbing ability of 3 day old park²⁵ flies.

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^Act5C.PU in park²⁵ flies improves their lifespan and resistance to paraquat.

(Costa et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^da.G32/Trap1^UAS.cCa rescues Trap1⁴

(Costa et al., 2013)

Comments

Expression of Trap1^Scer\UAS.cCa under the control of Scer\GAL4^da.G32 suppresses the impaired climbing ability of Trap1⁴ flies.

(Costa et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Trap1^Scer\UAS.cCa

Trap1^UAS.cCa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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