FlyBase Allele Report: Dmel\emb[E2-1A]

General Information

Symbol

Dmel\emb^E2-1A

Species

D. melanogaster

Name

FlyBase ID

FBal0283224

Feature type

allele

Associated gene

Dmel\emb

Associated Insertion(s)

P{EP}emb^E2-1A

Carried in Construct

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Insertion components

P{EP}emb^E2-1A

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

misexpression element

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

emb^E2-1A, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

emb^E2-1A/Scer\GAL4^GMR.PU is an enhancer of visible phenotype of hid^GMR.PG/W^GMR.PG

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

emb^E2-1A, Scer\GAL4^GMR.PU is a suppressor | partially of neuroanatomy defective | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

emb^E2-1A, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

emb^E2-1A, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

emb^E2-1A/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of hid^GMR.PG/W^GMR.PG

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

emb^E2-1A, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

emb^E2-1A, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

emb^E2-1A is a moderate suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Bilen and Bonini, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

emb^E2-1A

(Bilen and Bonini, 2007)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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