FB2019_05, released Oct 15, 2019

Allele: Dmel\Kdm2EP3093

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General Information
Symbol
Dmel\Kdm2EP3093
Species
D. melanogaster
Name
FlyBase ID
FBal0283227
Feature type
allele
Associated gene
Dmel\Kdm2
Associated Insertion(s)
P{EP}Kdm2EP3093
Carried in Construct
Genomic Maps
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    transposable element insertion site
    3R:9,052,484..9,052,484 [+]
    (Zheng et al., 2014, Bilen and Bonini, 2007)
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
         
        Progenitor genotype
        Cytology
        Nature of the lesion
        Statement
        Reference
        Insertion components
        P{EP}Kdm2EP3093
        Product class / Tool use(s)
        Regulatory region(s)
        UAS
        Encoded product / tool
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Machado-Joseph disease
        modeled by Hsap\ATXN3tr.Q61.UAS.Tag:HA
        (Bilen and Bonini, 2007)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Suppressor of
        Statement
        Reference
        Kdm2EP3093, Scer\GAL4GMR.PU is a suppressor of eye phenotype of Hsap\HSPA1LK71E.UAS, Scer\GAL4GMR.PU
        (Bilen and Bonini, 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Kdm2EP3093 is an enhancer of the eye degeneration phenotype caused by expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU. Co-expression of Kdm2EP3093 severely enhances pigment loss and internal retinal degeneration flies expressing Hsap\ATXN3tr.Q61.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.
        (Bilen and Bonini, 2007)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Outcrossing P{EP}Kdm2EP3093 with a wild type chromosome shows that the lethality is not associated with the insertion.
        (Zheng et al., 2014)
        Separable from: a lethal mutation.
        (Zheng et al., 2014)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG11033EP3093
        (Bilen and Bonini, 2007)
        Kdm2EP3093
        dKdm2EP3093#
        (Zheng et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)