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General Information
Symbol
Dmel\LamCUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Gurudatta
FlyBase ID
FBal0283352
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-lamC
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a full-length LamC cDNA.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of LamCUAS.cGa under the control of Scer\GAL4Act5C.PI results in death of the majority of animals at the larval stage, with the remainder dying shortly after pupation.
Overexpression of LamCScer\UAS.cGa under the control of Scer\GAL4elav.PU does not affect central nervous system development and adult flies are normal. Scer\GAL4Ubx-lac1-Gal4-mediated LamCScer\UAS.cGa expression in the wing disc gives rise to aberrant nuclear morphology. LamCScer\UAS.cGa expression mediated by the early muscle-specific driver Scer\GAL4how-24B leads to severe defects in the formation of larval longitudinal muscles and, probably as a consequence, lethality at the first instar larval stage. Scer\GAL4pnr-MD237-mediated LamCScer\UAS.cGa expression leads to the disorganization of dorsal indirect flight muscles in the adult. Overexpression of LamCScer\UAS.cGa under the control of Scer\GAL4ptc-559.1 leads to extensive apoptotic cell death along the anterior-posterior boundary in wing discs. Compared with surrounding tissue, highly condensed nuclei are observed in the Scer\GAL4ptc-559.1-domain where LamCScer\UAS.cGa is overexpressed.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of LamCUAS.cGa and lncRNA:HsrωdsRNA.Sym.UAS under the control of Scer\GAL4Act5C.PI delays the lethality seen with LamCUAS.cGa/Scer\GAL4Act5C.PI, so that most die as pupae or pharate adults; the majority of pharates show a severe head capsule defect, with loss of most head structures; the few adults that emerge are all female.
Xenogenetic Interactions
Statement
Reference
The abnormal nuclear morphology and apoptosis caused by the overexpression of LamCScer\UAS.cGa under the control of Scer\GAL4ptc-559.1 is suppressed by BacA\p35Scer\UAS.cHa.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
LamCScer\UAS.cGa
LamCUAS.cGa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Gurudatta
Secondary FlyBase IDs
    References (2)