FB2025_05 , released December 11, 2025
Allele: Hsap\PIK3CDp37δ.UAS
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General Information
Symbol
Hsap\PIK3CDp37δ.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0283530
Feature type
allele
Associated gene
Hsap\PIK3CD
Associated Insertion(s)
Carried in Construct
PBac{UAS-p37δ.F}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Fransson et al., 2012)
Progenitor genotype
Carried in construct
PBac{UAS-p37δ.F}
Cytology
Description

UASt regulatory sequences drive expression of the Hsap\PIK3CD p37δ isoform.

(Fransson et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PIK3CD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of Hsap\PIK3CDp37δ.Scer\UAS driven by Scer\GAL4da.PU does not significantly alter lifespan, over-expression driven by Scer\GAL4en.PU does not significantly affect pupal size, and over-expression driven by Scer\GAL4Bx-MS1096 does not significantly affect wing size compared to controls.

      (Ejeskär et al., 2015)

      Flies expressing Hsap\PIK3CDp37δ.Scer\UAS under the control of Scer\GAL4da.G32 show a significant increase in total body weight compared to controls. This correlates with elevated DNA content. Wings are larger than normal due to an increase in cell number.

      (Fransson et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\PIK3CDp37δ.Scer\UAS suppresses embryonic lethality seen with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4da.PU.

      Co-expression of Hsap\PIK3CDp37δ.Scer\UAS suppresses the small body phenotype in larvae with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4da.PU, but larvae remain developmentally delayed and retain fat body abnormalities.

      Co-expression of Hsap\PIK3CDp37δ.Scer\UAS significantly partially suppresses the reduced pupa size seen with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4en.PU.

      Co-expression of Hsap\PIK3CDp37δ.Scer\UAS does not suppress the reduced wing size seen with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4Bx-MS1096.

      (Ejeskär et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PIK3CDp37δ.Scer\UAS
      Hsap\PIK3CDp37δ.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)