upd3Δ mutant adults fail to increase the level of cell proliferation (number of EdU+ cells) in the posterior midgut epithelium upon refeeding (starvation followed by 24h of refeeding) as is normally observed in controls.
Unlike wild-type, the survival of adult upd3Δ mutants is not reduced by lipid-rich diet compared to flies kept on standard diet.
Expression of upd3Scer\UAS.cUa under the control of Scer\GAL4Hml.Δ in the upd3Δ hemizygote background reduces the lifespan of upd3Δ hemizygote males on a standard diet.
upd3Δ/upd3Δ adult flies have an increased survival after bacterial inoculation with Providencia rettgeri, but no obvious changes when infected with Enterococcus faecalis.
Mutants do not show any major developmental defects.
The response of increased proliferation of intestinal stem cells which is seen in wild-type flies after oral infection with Erwinia carotovora carotovora 15 is reduced in mutant flies compared to wild type.
Mutant flies show reduced survival compared to controls after oral infection with Erwinia carotovora carotovora 15.