FlyBase Allele Report: Dmel\Oli[UAS.cOa]

General Information

Symbol

Dmel\Oli^UAS.cOa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Oyallon

FlyBase ID

FBal0284098

Feature type

allele

Associated gene

Dmel\Oli

Associated Insertion(s)

Carried in Construct

P{UAS-Oli.O}

Key Links

Transgenic product class

cDNA

(Oyallon et al., 2012)

wild_type

(Oyallon et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Oyallon et al., 2012)

wild_type

(Oyallon et al., 2012)

Mutagen

in vitro construct

(Oyallon et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Oli.O}

Cytology

Description

UASt regulatory sequences drive expression of the Oli GH17679 cDNA.

(Oyallon et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Oli

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav-C155

(Oyallon et al., 2012)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^sca.PU

(Oyallon et al., 2012)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^elav-C155

(Oyallon et al., 2012)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^sca.PU

(Oyallon et al., 2012)

Detailed Description

Statement

Reference

ISNb motorneuron axons do not correctly defasciculate from each other, resulting in a failure to innervate their target muscles, in 49.1% of hemisegments in embryos expressing Oli^Scer\UAS.cOa under the control of Scer\GAL4^elav-C155.

ISNb motorneuron axons do not correctly defasciculate from each other, resulting in a failure to innervate their target muscles, in 25.6% of hemisegments in embryos expressing Oli^Scer\UAS.cOa under the control of Scer\GAL4^sca.PU.

(Oyallon et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^elav-C155/Oli^UAS.cOa partially rescues Oli^Δ9

(Oyallon et al., 2012)

Scer\GAL4^sca.PU/Oli^UAS.cOa partially rescues Oli^Δ9

(Oyallon et al., 2012)

Scer\GAL4^VGlut1-OK371/Oli^UAS.cOa partially rescues Oli^Δ9

(Oyallon et al., 2012)

Fails to rescue

Oli^UAS.cOa/Scer\GAL4^repo fails to rescue Oli^Δ9

(Oyallon et al., 2012)

Comments

Expression of Oli^Scer\UAS.cOa under the control of Scer\GAL4^elav-C155 fails to rescue the motorneuron axon targeting defects seen in Oli^Δ9 embryos. Survival to adulthood and adult locomotor defects are significantly rescued.

Expression of Oli^Scer\UAS.cOa under the control of Scer\GAL4^sca.PU partially rescues the motorneuron axon targeting defects seen in Oli^Δ9 embryos. Survival to adulthood and adult locomotor defects are significantly rescued.

Expression of Oli^Scer\UAS.cOa under the control of Scer\GAL4^repo fails to rescue eclosion rates or walking defects in Oli^Δ9 adults.

Expression of Oli^Scer\UAS.cOa under the control of Scer\GAL4^VGlut-OK371 partially rescues eclosion rates and walking defects in Oli^Δ9 adults.

(Oyallon et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Oli^Scer\UAS.cOa

Oli^UAS.cOa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Oyallon

Secondary FlyBase IDs

References (1)

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