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General Information
Symbol
Dmel\POSHp92
Species
D. melanogaster
Name
FlyBase ID
FBal0284329
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
A 425 bp deletion resulting from the imprecise excision of P{EP}POSHEP1206, removes the ATG and N-terminal coding sequences of POSH. The flanking sequences to the deletion are : 5′-GCCACGAG-3′ & 3′-TTCATCAT-5′.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of P{EP}POSHEP1206.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Approximately 5% of the homozygous POSHp92 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure. Approximately 6% of POSHk15815/POSHp92 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure. Approximately 10% of POSHp92/Df(2R)BSC45 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure. Approximately 9% of the homozygous POSHp92 embryos display head involution defects. Approximately 16% of the homozygous POSHp92 embryos display germ-band retraction defects. Approximately 70% of the homozygous POSHp92 embryos fail to hatch. Approximately 9% of the POSHk15815/POSHp92 embryos display head involution defects. Approximately 10% of the POSHk15815/POSHp92 embryos display germ-band retraction defects. Only 12.5% of the POSHk15815/POSHp92 embryos hatch to the first instar larval stage. Approximately 4% of the POSHp92/Df(2R)BSC45 embryos display head involution defects. Approximately 7% of the POSHp92/Df(2R)BSC45 embryos display germ-band retraction defects. 62% of the POSHp92/Df(2R)BSC45 embryos hatch to the first instar larval stage.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Over-expression of POSHScer\UAS.cSa under the control of Scer\GAL4pnr-MD237 fails to rescue the lethality and morphological defects in POSHk15815 and POSHp92 mutants.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
POSHp92
Name Synonyms
Secondary FlyBase IDs
    References (1)