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General Information
Symbol
Dmel\wgn22
Species
D. melanogaster
Name
FlyBase ID
FBal0284369
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Scer\FRT-mediated recombination has produced a line in which the insertion is still present but deletion of approximately 1200bp of genomic sequence flanking the 5' end of the insertion has occurred.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous third instar larvae have large gaps in the lamina with numerous abnormal thick axon bundles projecting into the medulla. Many mistargeted R2-R5 axons project into the medulla. This phenotype is 100% penetrant. The morphology of the R8 growth cones is abnormal.

Homozygous R8 axon MARCM clones show severe targeting defects, failing to stay in their appropriate target zones and straying into neighbouring regions. Homozygous R2-R5 axon MARCM clones show appropriate targeting to the lamina region.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of wgnScer\UAS.cRa.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU rescues the R2-R5 axon targeting defects seen in wgn22 hemizygotes in 37.5% of cases.

Expression of wgnScer\UAS.cRa.T:Zzzz\FLAG under the control of Scer\GAL4sca-109-68 rescues the R2-R5 axon targeting defects seen in wgn22 hemizygotes in 66.7% of cases.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)