Open Close
General Information
Symbol
Dmel\Nmdar1N631Q.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0284429
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a mutated form of Nmdar1, which contains the amino acid replacement N631Q.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Nmdar1N631Q.Scer\UAS under the control of Scer\GAL4elav.PU show normal learning (memory measured immediately after conditioning) and short-term memory (assayed 1 hour after training) in an aversive olfactory conditioning assay. One-day memory after spaced training (long-term memory) is reduced compared to wild type, while one-day memory after massed training (anesthesia-resistant memory) is normal.

Acute expression of Nmdar1N631Q.Scer\UAS under the control of Scer\GAL4elav.Switch.PO (by feeding 1mM RU486 starting one day prior to training) disrupts one-day long term memory in an aversive olfactory conditioning assay, while anesthesia-resistant memory is unaffected.

Expression of Nmdar1N631Q.Scer\UAS under the control of either Scer\GAL4Feb170, Scer\GAL4ey-OK107, Scer\GAL4c309 or Scer\GAL4C42 disrupts long-term memory in an aversive olfactory conditioning assay, while anesthesia-resistant memory is unaffected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Nmdar1N631Q.Scer\UAS under the control of Scer\GAL4elav.PU rescues the learning defects seen in Nmdar1EP331 flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nmdar1N631Q.Scer\UAS
Nmdar1N631Q.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)