amorphic allele - genetic evidence
R173term | corolla-PA; R171term | corolla-PB
Nucleotide substitution: A2759T.
Amino acid replacement: ?173term.
meiotic cell cycle defective
meiotic cell cycle defective (with corollad01774)
meiotic cell cycle defective (with Df(1)BSC583)
meiotic cell cycle defective (with Df(1)BSC643)
meiotic cell cycle defective | female
chromosome, centromeric region
corolla1 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.
corolla1, corolla1/corollad01774, corolla1/Df(1)BSC643 and corolla1/Df(1)BSC583 mutants exhibit elevated levels of X and 4th meiotic chromosome nondisjunction.
Synaptonemal complex formation is completely abolished in corolla1 mutants.
corolla1 oocytes show a strong defect in centromere clustering and centromere pairing.
corolla1 oocytes show a reduced number of double-strand breaks compared to controls (all assayed in a okrAA/okrRU background.
corolla1 mutants show no recombination throughout most of the euchromatin and exhibit a reduced frequency of recombination in the centromere-proximal region.
Homozygous females show 42.2% X chromosome nondisjunction and 33.4% 4th chromosome nondisjunction.
corolla1 is rescued by corolla+tCa
corolla+tCa fully suppresses the meiotic nondisjunction phenotype and defective synaptonemal complex seen in corolla1 mutants.