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General Information
Symbol
Dmel\corolla1
Species
D. melanogaster
Name
FlyBase ID
FBal0284453
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A17631262T

Reported nucleotide change:

A2759T

Amino acid change:

R173term | corolla-PA; R171term | corolla-PB

Reported amino acid change:

?173term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: A2759T.

Amino acid replacement: ?173term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

corolla1 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

corolla1, corolla1/corollad01774, corolla1/Df(1)BSC643 and corolla1/Df(1)BSC583 mutants exhibit elevated levels of X and 4th meiotic chromosome nondisjunction.

Synaptonemal complex formation is completely abolished in corolla1 mutants.

corolla1 oocytes show a strong defect in centromere clustering and centromere pairing.

corolla1 oocytes show a reduced number of double-strand breaks compared to controls (all assayed in a okrAA/okrRU background.

corolla1 mutants show no recombination throughout most of the euchromatin and exhibit a reduced frequency of recombination in the centromere-proximal region.

Homozygous females show 42.2% X chromosome nondisjunction and 33.4% 4th chromosome nondisjunction.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

corolla+tCa fully suppresses the meiotic nondisjunction phenotype and defective synaptonemal complex seen in corolla1 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)