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General Information
Symbol
Dmel\Cog7z-4495
Species
D. melanogaster
Name
FlyBase ID
FBal0284626
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Cog7z4495
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G29932576A

    Amino acid change:

    W134term | Cog7-PA

    Reported amino acid change:

    W134term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: ??term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Cog7z-4495/Cog7z-5797 transheterozygotes exhibit pronounced locomotor defects: larvae show irregular crawling with more turns and shorter distances, decreased frequency of peristaltic contractions and decreased distance per contraction, as compared to controls; adults show decreased climbing ability, as compared to controls. These individuals also show a held-out wing phenotype and present heat sensitive paralysis (38[o]C). About half spermatids in testes are multinucleate, indicating cytokinesis failure.

    Cog7z-4495/Cog7z-5797 transheterozygous larvae show exhibit neuromuscular junctions with significantly fewer boutons, but similar primary branch number, as compared to controls.

    The majority of spermatids are multinucleate, suggesting a failure of meiotic cytokinesis, in homozygous, Cog7z-4495/Cog7z-5797, Cog7z-4495/Cog7z-2805 and Cog7z-4495/Df(3R)BSC861 males.

    Cog7z-4495/Cog7z-5797 males show a failure of spermatid elongation.

    The F-actin rings fail to constrict to completion and the central spindles appear less dense than wild type in 80% of mid-late telophase I figures in Cog7z-4495/Df(3R)BSC861 spermatocytes.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    Cog7z-4495/Cog7z-5797 has paralytic | adult stage | heat sensitive phenotype, enhanceable by SiaT[+]/SiaTL22

    Cog7z-4495/Cog7z-5797 has paralytic | adult stage | heat sensitive phenotype, enhanceable by sauZ2217/sau[+]

    Suppressed by
    Other
    Phenotype Manifest In
    Suppressed by
    Enhancer of
    Statement
    Reference

    Cog7[+]/Cog7z-4495 is an enhancer of spermatid phenotype of sauZ2217/Df(2L)Exel7010

    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    sauZ2217/sauZ2217, Cog7z-4495/+ adults exhibit held-out wings, which also appear swollen and crumpled.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (3)