FlyBase Allele Report: Dmel\Nlg2[CL5]

General Information

Symbol

Dmel\Nlg2^CL5

Species

D. melanogaster

Name

FlyBase ID

FBal0285173

Feature type

allele

Associated gene

Dmel\Nlg2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

FLPase

Nature of the Allele

Allele class

Mutagen

FLPase

(Chen et al., 2012)

Progenitor genotype

P{XP}d02251

(Chen et al., 2012)

PBac{WH}Polr1F^f04579

(Chen et al., 2012)

Caused by aberration

Df(2L)Nlg2^CL5

Cytology

Description

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them. This 32.6kb deletion removes Nlg2 and CG13773.

(Chen et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:6,874,419..6,907,036 [+]

Comment:

32.6 kb deletion of Nlg2 and Polr1F resulting from FLP-catalyzed recombination using the FRT-containing transposons P{XP}d02251 and PBac{WH}Polr1F^f04579.

(Chen et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Chen et al., 2012)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage

(Ramesh et al., 2021)

muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage

(Ramesh et al., 2021)

presynaptic active zone

(Ramesh et al., 2021)

presynaptic active zone | increased number

(Ramesh et al., 2021)

Detailed Description

Statement

Reference

Nlg2^CL5 homozygous third instar larvae show NMJs with more but smaller active zones, as compared to controls.

(Ramesh et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Nlg2^CL5 has presynaptic active zone | increased number phenotype, non-enhanceable by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, non-enhanceable by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, non-enhanceable by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, non-enhanceable by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone | increased number phenotype, non-enhanceable by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, non-enhanceable by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Suppressed by

Statement

Reference

Nlg2^CL5 has presynaptic active zone | increased number phenotype, suppressible by +/Df(3R)RhoGAP100F^ex3.4

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, suppressible by +/Df(3R)RhoGAP100F^ex3.4

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, suppressible by +/Df(3R)RhoGAP100F^ex3.4

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by +/Df(3R)RhoGAP100F^ex3.4

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, suppressible by Nlg1[+]/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone | increased number phenotype, suppressible by Nlg1[+]/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, suppressible by Nlg1[+]/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Nlg1[+]/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone | increased number phenotype, suppressible by Nrx-1[+]/Nrx-1²⁴¹

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, suppressible by Nrx-1[+]/Nrx-1²⁴¹

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Nrx-1[+]/Nrx-1²⁴¹

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, suppressible by Nrx-1[+]/Nrx-1²⁴¹

(Ramesh et al., 2021)

NOT suppressed by

Statement

Reference

Nlg2^CL5 has presynaptic active zone | increased number phenotype, non-suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, non-suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, non-suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone | increased number phenotype, non-suppressible by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has presynaptic active zone phenotype, non-suppressible by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, non-suppressible by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

Nlg2^CL5 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Df(3L)BSC116/Df(3L)Spn-Δ3.1

(Ramesh et al., 2021)

NOT Suppressor of

Statement

Reference

Nlg2[+]/Nlg2^CL5 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Nrx-1²⁴¹/Df(3R)5C1

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype of Nrx-1²⁴¹/Df(3R)5C1

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of presynaptic active zone | decreased number phenotype of Nlg1^ex1.9/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of presynaptic active zone phenotype of Nlg1^ex1.9/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Nlg1^ex1.9/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype of Nlg1^ex1.9/Nlg1^ex2.3

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of presynaptic active zone | decreased number phenotype of Nrx-1²⁴¹/Df(3R)5C1

(Ramesh et al., 2021)

Nlg2[+]/Nlg2^CL5 is a non-suppressor of presynaptic active zone phenotype of Nrx-1²⁴¹/Df(3R)5C1

(Ramesh et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Nlg2^CL5 is rescued by Scer\GAL4^Mef2.PU/Nlg2^UAS.cUa

(Ramesh et al., 2021)

Not rescued by

Nlg2^CL5 is not rescued by Scer\GAL4^RapGAP1-OK6/Nlg2^UAS.cUa

(Ramesh et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nlg2^CL5

(Ramesh et al., 2021)

dnlg2^CL5

(Chen et al., 2012)

dnlg2^Δ

(Chen et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

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