Flies mutant for Ras85DR68Q exhibit a number of developmental defects that are characteristic of abnormally elevated RTK/RAS/MAPK signaling, including enhanced resistance to apoptosis, supernumerary R7 cells in the eye and ectopic wing vein formation.
Ras85DR68Q mutants have a reduced basal level of GTPase activity.
Ras85DR68Q mutants exhibit a statistically significant increase in the number of midline glia cells at stage 17 of embryogenesis, compared to controls.
Ras85DR68Q mutants exhibit supernumerary R7 cells in the developing ommatidia. Occasionally, ommatidia are found without outer photoreceptor cells, a phenotypic consequence of elevated MAPK signaling.
Ras85DR68Q flies show abnormalities in adult wing tissues. Homozygous Ras85DR68Q flies have an extra longitudinal 'veinlet' branching off the posterior crossvein. Additionally, an ectopic longitudinal vein is seen beneath the posterior crossvein and there is an ectopic crossvein found between the L4 and L5 wing veins near the hinge.