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General Information
Symbol
Dmel\MAGEXL
Species
D. melanogaster
Name
FlyBase ID
FBal0285379
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Deletion of the MAGE coding sequence as a result of ends-out gene targeting.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of the entire MAGE coding sequence. A single loxP site is present in place of the deleted sequence.

Insertion components
TI{TI}MAGEXL
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous, MAGEXL/MAGERZ and MAGEXL/Df(3R)Antp1 animals show caffeine-dependent lethality.

Dramatically increased apoptotic cell death is observed in the eye discs of MAGERZ/MAGEXL larvae after 12 hours exposure to caffeine.

Homozygous, MAGERZ/MAGEXL and MAGEXL/Df(3R)Antp1 animals show reduced survival after irradiation compared to controls.

BrdU incorporation in eye imaginal discs is abolished by hydroxyurea treatment in MAGERZ/MAGEXL larvae, as occurs in wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

The caffeine-dependent lethality of MAGEXL is rescued by MAGE+t4.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
MAGEXL
Name Synonyms
Secondary FlyBase IDs
    References (1)