FlyBase Allele Report: Dmel\HDAC6[H237A.UAS]

General Information

Symbol

Dmel\HDAC6^H237A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0285433

Feature type

allele

Associated gene

Dmel\HDAC6

Associated Insertion(s)

Carried in Construct

P{UAS-HDAC6.H237A}

Key Links

Transgenic product class

missense_variant

(Xiong et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Xiong et al., 2013)

Mutagen

in vitro construct

(Xiong et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-HDAC6.H237A}

Cytology

Description

UAS regulatory sequences drive expression of HDAC6 containing the amino acid replacement H237A.

(Xiong et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

HDAC6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

microtubule | larval stage, with Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

type Ib terminal bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

(Saunders et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

HDAC6^H237A.UAS, Scer\GAL4^RapGAP1-OK6 has microtubule | larval stage phenotype, non-enhanceable by αTub84B^K394R/αTub84B^K394R

(Saunders et al., 2022)

NOT suppressed by

Statement

Reference

HDAC6^H237A.UAS, Scer\GAL4^RapGAP1-OK6 has microtubule | larval stage phenotype, non-suppressible by αTub84B^K394R/αTub84B^K394R

(Saunders et al., 2022)

NOT Enhancer of

Statement

Reference

Scer\GAL4^RapGAP1-OK6/HDAC6^H237A.UAS is a non-enhancer of microtubule | larval stage phenotype of αTub84B^K394R

(Saunders et al., 2022)

NOT Suppressor of

Statement

Reference

Scer\GAL4^RapGAP1-OK6/HDAC6^H237A.UAS is a non-suppressor of microtubule | larval stage phenotype of αTub84B^K394R

(Saunders et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^C57/HDAC6^H237A.UAS rescues HDAC6^KO

(Xiong et al., 2013)

Comments

Expression of HDAC6^{H237A.Scer\UAS} under the control of Scer\GAL4^C57 completely suppresses the ability of HDAC6^KO to rescue the perinuclear microtubule density defects seen in the muscles of animals expressing either Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^C57.

(Xiong et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51183

y¹ w^*; P{UAS-HDAC6.H237A}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HDAC6^{H237A.Scer\UAS}

HDAC6^H237A.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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