FB2025_01 , released February 20, 2025
Allele: Dmel\HDAC6H237A.H664A.UAS
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General Information
Symbol
Dmel\HDAC6H237A.H664A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285435
Feature type
allele
Associated gene
Dmel\HDAC6
Associated Insertion(s)
Carried in Construct
P{UAS-HDAC6.H237A.H664A}
Key Links
Transgenic product class
missense_variant
(Xiong et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Xiong et al., 2013)
Mutagen
in vitro construct
(Xiong et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-HDAC6.H237A.H664A}
Cytology
Description

UAS regulatory sequences drive expression of HDAC6 containing the amino acid replacements H237A and H664A.

(Xiong et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
HDAC6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Cheng et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4Mhc.PK/HDAC6H237A.H664A.UAS fails to rescue HDAC6KO

      (Yan et al., 2017)

      HDAC6H237A.H664A.UAS/Scer\GAL4C57 fails to rescue HDAC6KO

      (Xiong et al., 2013)
      Comments

      Expression of HDAC6H237A.H664A.Scer\UAS under the control of Scer\GAL4C57 does not affect the ability of HDAC6KO to rescue the perinuclear microtubule density defects seen in the muscles of animals expressing either Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4C57.

      (Xiong et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HDAC6H237A.H664A.Scer\UAS
      HDAC6H237A.H664A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)